

50 caliber Sharps, rifles, double rigs, shotguns, Gatling guns, and cannons. Additional weaponry can be found throughout the game that will give the player better firepower. To reload, the player must aim the lightgun away from the screen and pull the trigger. The player's gun (a six-shooter) can carry up to six bullets. Just like the original game, a dip switch setting in the arcade version allows operators to let players progress through the stages in a linear fashion ("arcade mode") or select individual stages ("street mode"), including the between level target practice stages. At the end of each stage, a boss must be killed in order to complete the stage (though a unique case happened in the third stage where the boss battle is in the form of a dueling mini-game). During each stage, the player must shoot the armed outlaws without harming any innocent townsfolk or fellow lawmen. Lethal Enforcers 2 has five stages: "The Bank Robbery", "The Stage-Holdup", "Saloon Showdown", "The Train Robbery", and "The Hide-Out".

The game ends when all life units are gone, but continue play is available. Every time the player is shot or an innocent townsperson or lawmen is shot, one life unit will be lost. Life units are also awarded based on how many points the player scores while playing the game. In the arcade version, more can be purchased by inserting additional coins. At the beginning of the game, three to five life units are available.

The object in the game is to shoot outlaws in order to eradicate crime from a stereotypical Old West town.
